| Dry compressed air | Brass or 316 stainless steel | NBR or FKM | Good | NBR: about 100 °C FKM: about 200 °C | Use FKM when compressor oil, elevated temperature, or ozone exposure is present. |
| Water and hot water | Brass for general service; 316 stainless steel for corrosive water | EPDM | Good | EPDM: about 150 °C | EPDM is generally preferred for hot water and steam; avoid it with petroleum oils and fuels. |
| Steam | 316 stainless steel or a steam-rated brass body | PTFE or steam-rated FKM | Good when rated | PTFE: about 200–260 °C FKM: about 150–200 °C | Confirm the valve’s pressure, saturated-steam temperature, and cycle-life rating; standard elastomers may degrade rapidly. |
| Mineral oil and lubricating oil | Brass or 316 stainless steel | NBR or FKM | Good | NBR: about 100 °C FKM: about 200 °C | NBR is economical for moderate temperatures; FKM offers better resistance to heat and many hydrocarbon oils. |
| Diesel fuel and gasoline | Aluminum, brass, or 316 stainless steel, subject to fuel composition | FKM | Good | FKM: about 200 °C | Fuel additives and alcohol content can change compatibility; verify the exact fuel formulation. |
| Dilute acids, such as citric acid | 316 stainless steel or PVC for suitable temperatures | PTFE or EPDM | Conditional | PTFE: about 200–260 °C EPDM: about 150 °C | Concentration, temperature, and exposure time strongly affect corrosion; PVC is limited by temperature and pressure. |
| Strong alkalis, such as sodium hydroxide | 316 stainless steel, PTFE-lined construction, or compatible plastic | PTFE or EPDM | Conditional | PTFE: about 200–260 °C EPDM: about 150 °C | Check caustic concentration and temperature; some stainless steels can suffer stress-corrosion or localized attack. |
| Alcohols and water-glycol mixtures | Brass or 316 stainless steel | EPDM or FKM | Conditional | EPDM: about 150 °C FKM: about 200 °C | EPDM is often suitable for glycol and water; FKM may be preferred for fuel-containing or higher-temperature mixtures. |
| Oxygen-enriched or high-purity oxygen | Cleaned 316 stainless steel | PTFE or oxygen-compatible EPDM | Special approval required | Depends on oxygen-service rating | Use only components cleaned and approved for oxygen service; oil and particulate contamination can create a fire hazard. |
| Refrigerants | Brass or 316 stainless steel | PTFE, FKM, or refrigerant-specific elastomer | Conditional | Typically about −40 to 150 °C, depending on seal | Refrigerant type, pressure, lubricant, and low-temperature flexibility must all be checked together. |